Molecular imaging of proteolytic activity in cancer.

  title={Molecular imaging of proteolytic activity in cancer.},
  author={J. Oliver McIntyre and Lynn M Matrisian},
  journal={Journal of cellular biochemistry},
  volume={90 6},
The early detection of both primary tumors and metastatic disease continue to be significant challenges in the diagnosis and staging of cancer. The growing recognition of the role of proteinases and proteolytic cascades in both the growth and metastasis of tumors has led to the development not only of therapeutic strategies using proteinase inhibitors, but also of methods to detect and image tumors in vivo via tumor-associated proteolytic activities. These imaging strategies derive from the… CONTINUE READING

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