Molecular imaging of glioblastoma multiforme using anti-insulin-like growth factor-binding protein-7 single-domain antibodies

@inproceedings{Iqbal2010MolecularIO,
  title={Molecular imaging of glioblastoma multiforme using anti-insulin-like growth factor-binding protein-7 single-domain antibodies},
  author={Umar Iqbal and Homam Albaghdadi and Yan Ting Luo and Mehdi Arbabi and C. Desvaux and Teodor Veres and Danica D Stanimirovic and Abedelnasser Abulrob},
  booktitle={British Journal of Cancer},
  year={2010}
}
Background:Insulin-like growth factor-binding protein 7 (IGFBP7) is an abundant, selective and accessible biomarker of glioblastoma multiforme (GBM) tumour vessels. In this study, an anti-IGFBP7 single-domain antibody (sdAb) was developed to target GBM vessels for molecular imaging applications.Methods:Human GBM was modelled in mice by intracranial implantation of U87MG.EGFRvIII cells. An anti-IGFBP7 sdAb, isolated from an immune llama library by panning, was assessed in vitro for its binding… CONTINUE READING
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