Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography.

@article{Nimmagadda2010MolecularIO,
  title={Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography.},
  author={Sridhar Nimmagadda and Mrudula Pullambhatla and Kristie Stone and Gilbert M. Green and Zaver M. Bhujwalla and Martin G. Pomper},
  journal={Cancer research},
  year={2010},
  volume={70 10},
  pages={
          3935-44
        }
}
The chemokine receptor CXCR4 and its cognate ligand CXCL12 are pivotal for establishing metastases from many tumor types. Thus, CXCR4 may offer a cell surface target for molecular imaging of metastases, assisting diagnosis, staging, and therapeutic monitoring. Furthermore, noninvasive detection of CXCR4 status of a primary tumor may provide an index of the metastatic potential of the lesion. Here, we report the development and evaluation of [(64)Cu]AMD3100, a positron-emitting analogue of the… CONTINUE READING

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