Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography.

Abstract

The chemokine receptor CXCR4 and its cognate ligand CXCL12 are pivotal for establishing metastases from many tumor types. Thus, CXCR4 may offer a cell surface target for molecular imaging of metastases, assisting diagnosis, staging, and therapeutic monitoring. Furthermore, noninvasive detection of CXCR4 status of a primary tumor may provide an index of the… (More)
DOI: 10.1158/0008-5472.CAN-09-4396

Topics

6 Figures and Tables

Cite this paper

@article{Nimmagadda2010MolecularIO, title={Molecular imaging of CXCR4 receptor expression in human cancer xenografts with [64Cu]AMD3100 positron emission tomography.}, author={Sridhar Nimmagadda and Mrudula Pullambhatla and Kristie Stone and Gilbert M. Green and Zaver M. Bhujwalla and Martin G. Pomper}, journal={Cancer research}, year={2010}, volume={70 10}, pages={3935-44} }