Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes.

@article{Archer1998MolecularIO,
  title={Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes.},
  author={Stephen L Archer and Evelyne Souil and Anh Tuan Dinh-Xuan and B. Schremmer and Jean Christophe Mercier and A el Yaagoubi and L Nguyen-Huu and Helen L. Reeve and V{\'a}clav Hampl},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={101 11},
  pages={2319-30}
}
Hypoxia initiates pulmonary vasoconstriction (HPV) by inhibiting one or more voltage-gated potassium channels (Kv) in the pulmonary artery smooth muscle cells (PASMCs) of resistance arteries. The resulting membrane depolarization increases opening of voltage-gated calcium channels, raising cytosolic Ca2+ and initiating HPV. There are presently nine families of Kv channels known and pharmacological inhibitors lack the specificity to distinguish those involved in control of resting membrane… CONTINUE READING
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