Molecular identification of t(w5): Vps52 promotes pluripotential cell differentiation through cell-cell interactions.

@article{Sugimoto2012MolecularIO,
  title={Molecular identification of t(w5): Vps52 promotes pluripotential cell differentiation through cell-cell interactions.},
  author={Michihiko Sugimoto and Masayo Kondo and Michiko Hirose and Misao Suzuki and Kazuyuki Mekada and Takaya Abe and Hiroshi Kiyonari and Atsuo Ogura and Nobuo Takagi and Karen Artzt and Kuniya Abe},
  journal={Cell reports},
  year={2012},
  volume={2 5},
  pages={1363-74}
}
After implantation, pluripotent epiblasts are converted to embryonic ectoderm through cell-cell interactions that significantly change the transcriptional and epigenetic networks. An entrée to understanding this vital developmental transition is the t(w5) mutation of the mouse t complex. This mutation produces highly specific defects in the embryonic ectoderm before gastrulation, leading to death of the embryonic ectoderm. Using a positional cloning approach, we have now identified the mutated… CONTINUE READING
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