Molecular identification of distinct neurogenic and melanogenic neural crest sublineages.

@article{Luo2003MolecularIO,
  title={Molecular identification of distinct neurogenic and melanogenic neural crest sublineages.},
  author={Rushu Luo and Juan Gao and Bernhard Wehrle-Haller and Paul D. Henion},
  journal={Development},
  year={2003},
  volume={130 2},
  pages={321-30}
}
Clonal and lineage analyses have demonstrated that although some neural crest cells have the ability to generate multiple cell types and display self-renewal ability, other crest cells generate a single or limited repertoire of cell types. However, it is not yet clear when, and in what order, crest cells become specified to adopt a particular fate. We report that the receptor tyrosine kinases TrkC and C-Kit are expressed by distinct neural crest subpopulations in vitro. We then analyzed the… CONTINUE READING