Molecular identification of a volume-regulated chloride channel

  title={Molecular identification of a volume-regulated chloride channel},
  author={Dayue Darrel Duan and Cathy Winter and Suzanne Cowley and Joseph R. Hume and Burton Horowitz},
A volume-regulated chloride current ( I Cl.vol) is ubiquitously present in mammalian cells, and is required for the regulation of electrical activity, cell volume, intracellular pH, immunological responses, cell proliferation and differentiation. However, the molecule responsible for I Cl.vol has yet to be determined. Although three putative chloride channel proteins expressed from cloned genes (P-glycoprotein, p I Cln (ref. 5) and ClC-2 (ref. 6)) have been proposed to be the molecular… CONTINUE READING
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