Molecular identification of a volume-regulated chloride channel

@article{Duan1997MolecularIO,
  title={Molecular identification of a volume-regulated chloride channel},
  author={Dayue Darrel Duan and Cathy Winter and Suzanne Cowley and Joseph R. Hume and Burton Horowitz},
  journal={Nature},
  year={1997},
  volume={390},
  pages={417-421}
}
A volume-regulated chloride current ( I Cl.vol) is ubiquitously present in mammalian cells, and is required for the regulation of electrical activity, cell volume, intracellular pH, immunological responses, cell proliferation and differentiation. However, the molecule responsible for I Cl.vol has yet to be determined. Although three putative chloride channel proteins expressed from cloned genes (P-glycoprotein, p I Cln (ref. 5) and ClC-2 (ref. 6)) have been proposed to be the molecular… CONTINUE READING
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