Molecular heterogeneity and prognostic biomarkers in adults with acute myeloid leukemia and normal cytogenetics.

@article{Marcucci2005MolecularHA,
  title={Molecular heterogeneity and prognostic biomarkers in adults with acute myeloid leukemia and normal cytogenetics.},
  author={Guido Marcucci and Krzysztof Mr{\'o}zek and Clara D. Bloomfield},
  journal={Current opinion in hematology},
  year={2005},
  volume={12 1},
  pages={68-75}
}
PURPOSE OF REVIEW Patients with acute myeloid leukemia (AML) and normal karyotype constitute the single largest cytogenetic group of AML, estimated to account for 45% of adults with de novo AML. This article critically reviews the recent literature that addresses the molecular heterogeneity of this group of patients and how this relates to prognostic stratification and novel therapeutic approaches. RECENT FINDINGS Four prognostic biomarkers-the internal tandem duplication and point mutations… CONTINUE READING