Molecular genotyping shows that ataxia-telangiectasia heterozygotes are predisposed to breast cancer.

@article{Athma1996MolecularGS,
  title={Molecular genotyping shows that ataxia-telangiectasia heterozygotes are predisposed to breast cancer.},
  author={Prasanna Athma and Rapha{\"e}l Rappaport and Michael J. Swift},
  journal={Cancer genetics and cytogenetics},
  year={1996},
  volume={92 2},
  pages={
          130-4
        }
}
About 1.4% of the general population are heterozygous carriers of the gene for ataxiatelangiectasia (A-T), an autosomal recessive progressive neurologic syndrome in which cancer incidence of homozygotes is approximately 100-fold greater than the general population's rates. The hypothesis that A-T heterozygotes are predisposed to breast cancer was tested by the unbiased statistically powerful index-test method based on molecular genotyping. The A-T gene carrier status of 775 blood relatives in… CONTINUE READING

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