Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse.

@article{Sohn2001MolecularGO,
  title={Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse.},
  author={Kyoung Jin Sohn and Syed Qarib Abbas Shah and Sarah Reid and Mieyoung Choi and Julie Carrier and Martina Comiskey and Cox Terhorst and Yuri Kim},
  journal={Cancer research},
  year={2001},
  volume={61 18},
  pages={
          6912-7
        }
}
Mice deficient in beta(2)-microglobulin and interleukin 2 (beta(2)m(null) x IL-2(null)) spontaneously develop colon cancer in the setting of chronic ulcerative colitis (UC). We investigated mutations of the Apc and p53 genes and microsatellite instability in colonic adenocarcinomas arising in this model. Mutations of the Apc and p53 genes in the regions corresponding to mutation hot spots in human colorectal cancer were determined by sequencing in 11 colonic adenocarcinomas. Microsatellite… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 16 CITATIONS, ESTIMATED 36% COVERAGE

52 Citations

051015'02'05'09'13'17
Citations per Year
Semantic Scholar estimates that this publication has 52 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 64 REFERENCES

The effect of dietary folate on Apc and p53 mutations in the dimethylhydrazine rat model of colorectal cancer

  • Sohn, K-J, +7 authors Y. I. Kim
  • Carcinogenesis (Lond.),
  • 1999
Highly Influential
6 Excerpts

Evidence that CD4

  • S. J. Simpson, E. Mizoguchi, D. Allen, A. K. Bhan, C. Terhorst
  • Eur. J. Immunol.,
  • 1995
Highly Influential
4 Excerpts

Effects of dietary folate on somatic APC mutations in APC / MSH2 / mice

  • Sohn, K-J, +4 authors Y. I. Kim
  • Proc. Am. Assoc. Cancer Res.,
  • 2000
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…