Molecular genetics of thyroid cancer: implications for diagnosis, treatment and prognosis.

@article{Nikiforova2008MolecularGO,
  title={Molecular genetics of thyroid cancer: implications for diagnosis, treatment and prognosis.},
  author={Marina N. Nikiforova and Yuri E Nikiforov},
  journal={Expert review of molecular diagnostics},
  year={2008},
  volume={8 1},
  pages={83-95}
}
Thyroid cancer is the most common malignant tumor of the endocrine system and accounts for approximately 1% of all newly diagnosed cancer cases. The most frequent type of thyroid malignancy is papillary carcinoma, which constitutes approximately 80% of all cases. Papillary carcinomas frequently have genetic alterations leading to the activation of the MAPK signal pathway. Those include RET/PTC rearrangement and point mutations of the BRAF and RAS genes. Mutations in these genes are found in… CONTINUE READING

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