Molecular genetics of the single-minded locus: a gene involved in the development of the Drosophila nervous system.

@article{Thomas1988MolecularGO,
  title={Molecular genetics of the single-minded locus: a gene involved in the development of the Drosophila nervous system.},
  author={John Bob Thomas and Stephen T. Crews and Corey S. Goodman},
  journal={Cell},
  year={1988},
  volume={52 1},
  pages={133-41}
}
The embryonic neuroepithelium of Drosophila gives rise to the central nervous system. We have studied the mutant phenotype and expression of a gene, single-minded (sim), which is involved in generating a specific region of this neuroepithelium. In sim mutant embryos, a subset of neuronal and nonneuronal precursor cells lying along the midline fail to emerge with the rest of the neuroepithelium. We have identified the sim transcription unit and have shown by in situ hybridization to embryos that… CONTINUE READING