Molecular genetics of speciation and human origins.

@article{Ayala1994MolecularGO,
  title={Molecular genetics of speciation and human origins.},
  author={Francisco Jos{\'e} Ayala and Anan{\'i}as A. Escalante and Colm O'huigin and Jan Klein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 15},
  pages={
          6787-94
        }
}
  • F. Ayala, A. Escalante, J. Klein
  • Published 19 July 1994
  • Biology
  • Proceedings of the National Academy of Sciences of the United States of America
The major histocompatibility complex (MHC) plays a cardinal role in the defense of vertebrates against parasites and other pathogens. In some genes there are extensive and ancient polymorphisms that have passed from ancestral to descendant species and are shared among contemporary species. The polymorphism at the DRB1 locus, represented by 58 known alleles in humans, has existed for at least 30 million years and is shared by humans, apes, and other primates. The coalescence theory of… 

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