Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage

  title={Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage},
  author={Hubertus Haas},
  journal={Applied Microbiology and Biotechnology},
  • H. Haas
  • Published 21 May 2003
  • Biology
  • Applied Microbiology and Biotechnology
To acquire iron, all species have to overcome the problems of iron insolubility and toxicity. In response to low iron availability in the environment, most fungi excrete ferric iron-specific chelators—siderophores—to mobilize this metal. Siderophore-bound iron is subsequently utilized via the reductive iron assimilatory system or uptake of the siderophore-iron complex. Furthermore, most fungi possess intracellular siderophores as iron storage compounds. Molecular analysis of siderophore… 

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  • D. Howard
  • Biology
    Clinical Microbiology Reviews
  • 1999
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