Molecular genetics of colorectal cancer

  title={Molecular genetics of colorectal cancer},
  author={Julie A Bogaert and Hans Prenen},
  booktitle={Annals of gastroenterology},
Approximately 90% of colorectal cancer cases are sporadic without family history or genetic predisposition, while in less than 10% a causative genetic event has been identified. Historically, colorectal cancer classification was only based on clinical and pathological features. Many efforts have been made to discover the genetic and molecular features of colorectal cancer, and there is more and more evidence that these features determine the prognosis and response to (targeted) treatment… CONTINUE READING