Molecular genetics of Xeroderma pigmentosum variant.

  title={Molecular genetics of Xeroderma pigmentosum variant.},
  author={Alexei Gratchev and Pamela Strein and Jochen Sven Utikal and Goerdt Sergij},
  journal={Experimental dermatology},
  volume={12 5},
Xeroderma pigmentosum (XP) is an autosomal recessive disease characterized by sun sensitivity, early onset of freckling and subsequent neoplastic changes on sun-exposed skin. Skin abnormalities result from an inability to repair UV-damaged DNA because of defects in the nucleotide excision repair (NER) machinery. Xeroderma pigmentosum is genetically heterogeneous and is classified into seven complementation groups (XPA-XPG) that correspond to genetic alterations in one of seven genes involved in… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…