Molecular genetics of Drosophila alpha-actinin: mutant alleles disrupt Z disc integrity and muscle insertions

@article{Fyrberg1990MolecularGO,
  title={Molecular genetics of Drosophila alpha-actinin: mutant alleles disrupt Z disc integrity and muscle insertions},
  author={Eric A. Fyrberg and Mike Kelly and Elizabeth Ball and Christine C. Fyrberg and Mary C. Reedy},
  journal={The Journal of Cell Biology},
  year={1990},
  volume={110},
  pages={1999 - 2011}
}
We have isolated a Drosophila melanogaster alpha-actinin gene and partially characterized several mutant alleles. The Drosophila protein sequence is very similar (68% identity) to those of chicken alpha-actinin isoforms, but less closely related (30% identity) to Dictyostelium alpha-actinin. The gene is within subdivision 2C of the X chromosome, coincident with 15 lethal (1)2Cb mutations. At least four alleles, l(1)2Cb1, l(1)2Cb2, l(1)2Cb4, and l(1)2Cb5 are interrupted by rearrangement… CONTINUE READING