Molecular genetics of Crohn's disease.

  title={Molecular genetics of Crohn's disease.},
  author={Richard Russell and Elaine R. Nimmo and Jack Satsangi},
  journal={Current opinion in genetics & development},
  volume={14 3},
Progress in the genetics of complex diseases has been slow over the past two decades compared to many simple Mendelian traits. However, rapid advances are now being made in inflammatory bowel disease genetics, leading already to identification of the first gene linked to Crohn's disease susceptibility: NOD2/CARD15. Since its discovery three years ago, there has been replication of the association of NOD2/CARD15 mutations with Crohn's disease in many populations, together with identification of… CONTINUE READING