Molecular genetics and related developments in pancreatic cancer.

Abstract

Cancer of the pancreas is a genetic disease. The most common genetic alterations identified to date in pancreatic cancer are activation of the K-ras oncogene (approximately 90%) and inactivation of the p16 (approximately 95%), p53 (50% to 75%), DPC4 (55%), and BRCA2 (7%) tumor suppressor genes. An understanding of the molecular genetics of carcinoma of the… (More)

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@article{Hruban1999MolecularGA, title={Molecular genetics and related developments in pancreatic cancer.}, author={Ralph H. Hruban and Michael Goggins and S E Kern}, journal={Current opinion in gastroenterology}, year={1999}, volume={15 5}, pages={404-9} }