Molecular genetics and related developments in pancreatic cancer.

  title={Molecular genetics and related developments in pancreatic cancer.},
  author={Ralph H. Hruban and Michael Goggins and Scott E. Kern},
  journal={Current opinion in gastroenterology},
  volume={15 5},
Cancer of the pancreas is a genetic disease. The most common genetic alterations identified to date in pancreatic cancer are activation of the K-ras oncogene (approximately 90%) and inactivation of the p16 (approximately 95%), p53 (50% to 75%), DPC4 (55%), and BRCA2 (7%) tumor suppressor genes. An understanding of the molecular genetics of carcinoma of the pancreas is important because it may help explain the aggregation of pancreatic cancer in families and may lead to the development of novel… CONTINUE READING
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