Molecular genetic studies of cellular senescence

@article{Pereirasmith1992MolecularGS,
  title={Molecular genetic studies of cellular senescence},
  author={Olivia Pereira-smith and Yi Ning},
  journal={Experimental Gerontology},
  year={1992},
  volume={27},
  pages={519-522}
}

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It was found that at least two separate events in the normal cell genome can result in immortality, and in fusions involving certain immortal parent cells, these events can be complemented to result in hybrids with finite division capacity.

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Identification of participating genes and clarification of their mechanisms of action will help to elucidate the universal cellular decline of biological aging and an important obverse manifestation, the rare escape of cells from senescence leading to immortalization and oncogenesis.

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