Molecular genetic studies of cellular senescence

@article{Pereirasmith1992MolecularGS,
  title={Molecular genetic studies of cellular senescence},
  author={O. Pereira-smith and Y. Ning},
  journal={Experimental Gerontology},
  year={1992},
  volume={27},
  pages={519-522}
}
The limited doubling potential of normal cells in culture was first proposed as a model for cellular aging by Hayflick in 1961. This phenomenon of in vitro cellular senescence is now well documented for a number of different normal human cell types. In an attempt to determine whether random events or programmed genetic processes were responsible for cellular aging, we performed a series of cell fusion studies. We determined that hybrids from fusion of normal with immortal human cells had… Expand
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