Molecular genetic studies of bipolar disorder and puerperal psychosis at two polymorphisms in the estrogen receptor alpha gene (ESR 1).

@article{Jones2000MolecularGS,
  title={Molecular genetic studies of bipolar disorder and puerperal psychosis at two polymorphisms in the estrogen receptor alpha gene (ESR 1).},
  author={Ian Jones and Fiona Middle and Fiona McCandless and Nessa Coyle and Emma Robertson and Ian Fraser Brockington and Corinne L. Lendon and Nick J. Craddock},
  journal={American journal of medical genetics},
  year={2000},
  volume={96 6},
  pages={850-3}
}
A number of lines of evidence point to the possible involvement of estrogen pathways in the pathophysiology of bipolar disorder in general and puerperal psychosis in particular. There is strong evidence from clinical, follow-up, and genetic studies to support the hypothesis that most cases of puerperal psychosis are manifestations of an affective disorder diathesis with a puerperal trigger and that genes influence susceptibility to both diathesis and trigger. The nature of the trigger is… CONTINUE READING

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