Molecular genetic methods in the diagnosis of myelodysplastic syndromes. A review.

@article{Lukackova2013MolecularGM,
  title={Molecular genetic methods in the diagnosis of myelodysplastic syndromes. A review.},
  author={Renata Lukackova and Maria Gerykova Bujalkova and L Majerov{\'a} and Be{\'a}ta Mladosievi{\vc}ov{\'a}},
  journal={Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia},
  year={2013},
  volume={158 3},
  pages={
          339-45
        }
}
BACKGROUND Myelodysplastic syndromes (MDS) represent a heterogeneous group of premalignant hematologic disorders characterized by ineffective hematopoiesis, peripheral blood cytopenias and increased risk of progression to acute leukemia. Cytogenetic analysis still plays a central role in the diagnosis of MDS, as clonal chromosomal abnormalities are observed in 30-50% of MDS patients. Despite their technical limitations, standard karyotyping and fluorescence in situ hybridization (FISH) are… CONTINUE READING
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