Molecular genetic methods for improving secondary-metabolite production in actinomycetes.

@article{Baltz1996MolecularGM,
  title={Molecular genetic methods for improving secondary-metabolite production in actinomycetes.},
  author={Richard H. Baltz and Thomas J Hosted},
  journal={Trends in biotechnology},
  year={1996},
  volume={14 7},
  pages={245-50}
}
The practical applications of genetic engineering to improve secondary-metabolite production in actinomycetes are potentially numerous, but have been limited by: (1) restriction barriers, which can hinder the introduction of DNA into many actinomycetes; (2) self-replicating plasmid-cloning vectors, which generally inhibit secondary-metabolite production; and (3) recombinants containing heterologous DNA, which may be subject to additional regulatory hurdles. Recently, intergeneric conjugation… CONTINUE READING

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