Molecular genetic features reflecting the preference for isotype switching to IgA expression by Peyer's patch germinal center B cells.

Abstract

It has proven difficult to evaluate the functional potential of germinal center (GC) B cells, including those from Peyer's patches (PP), by either in vivo or in vitro methods. Thus, rather than assess secreted Ig product as an indicator of functional potential we have instead sought to detect mRNAs related to the various Ig heavy chains in GC B cells from… (More)

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