Molecular genetic basis of the histo-blood group ABO system

@article{Yamamoto1990MolecularGB,
  title={Molecular genetic basis of the histo-blood group ABO system},
  author={Fumiichiro Yamamoto and Henrik Clausen and Thayer White and John S. Marken and Sen‐itiroh Hakomori},
  journal={Nature},
  year={1990},
  volume={345},
  pages={229-233}
}
The histo-blood group ABO, the major human alloantigen system, involves three carbohydrate antigens (ABH). A, B and AB individuals express glycosyltransferase activities converting the H antigen into A or B antigens, whereas 0(H) individuals lack such activity. Here we present a molecular basis for the ABO genotypes. The A and B genes differ in a few single-base substitutions, changing four amino-acid residues that may cause differences in A and B transferase specificity. A critical single-base… Expand
Molecular aspects of ABO Blood Group System
TLDR
The variants of these alleles and the underlying mutations, deletions or rearrangement of the genes responsible for the occurrence of ABO subgroups and O transferases inactivation are described. Expand
Synthesis of ABO histo-blood group type I and II antigens.
TLDR
The synthesis of the type I and II antigens with a 7-octen-1-yl aglycone was chosen to facilitate not only the future conjugation of the antIGens to a protein or solid support but also the synthesis ofThe H type Iand II octyl glycosides for enzyme kinetic studies. Expand
Molecular genetic basis of porcine histo-blood group AO system.
TLDR
The porcine A gene is homologous to the ABO genes in humans and other species and encodes an alpha1 --> 3 N-acetyl-D-galactosaminyltransferase that synthesizes A antigens, which are important in transfusion and transplantation medicine. Expand
Cloning and regulation of the ABO genes
Histo-blood group A and B antigens are not protein antigens. Therefore, these antigens are not the primary gene products of A and B alleles at the ABO genetic locus. A and B antigens areExpand
Synthesis of ABO Histo-Blood Group Type V and VI Antigens*
The ABO histo-blood group antigens have long been of interest to chemists, biochemists, and evolutionary biologists. However, to date, a complete synthesis of all ABO histo-blood group antigens hasExpand
Molecular Genetics of the ABO Histo‐Blood Group System
TLDR
Comparison of the nucleotide sequence has identified in the coding region differences which change amino acid sequences of the glycosyltransferases coded by these genes. Expand
Characterization of a novel B(A) allele with BBBA type at the ABO blood group
TLDR
This work characterization of a novel B(A) allele which differs from those reported previously is reported, which is a type of dual ABO allele which can encode glycosyltransferases responsible for the conversion of H substance to both A and B antigen. Expand
Progress in the study of ABO blood group system.
TLDR
Progress in the study of ABO blood group system during the last three decades was reviewed and the cDNA structures of human blood group ABO genes were reviewed. Expand
Murine Equivalent of the Human Histo-blood Group ABO Gene Is acis-AB Gene and Encodes a Glycosyltransferase with Both A and B Transferase Activity*
TLDR
Cloned murine genomic and complementary DNA that is equivalent to the human ABO gene is cloned and may be helpful in establishing a mouse model system to assess the functionality of the ABO genes in the future. Expand
The Donor Cross-Specificity of Human Blood Group Aand B-Synthesizing Glycosyltransferases
TLDR
The human ABO blood group is the most clinically significant blood group system and is certainly the best known, but the unusual genotypes cis-AB and B(A) have raised some interest, and the enzymes expressed by them are providing great opportunities for functionstructure studies on this highly important system. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 32 REFERENCES
Incompatible A antigen expressed in tumors of blood group O individuals: immunochemical, immunohistologic, and enzymatic characterization.
TLDR
The incidence of A antigen expression in O tumors was found to be two out of 15 cases, based on TLC immunostaining of glycolipid extracts, and five out of 50 cases,based on immunofluorescent staining of tumors with AH21 and HH3 antibodies. Expand
ABH and Related Histo‐Blood Group Antigens; Immunochemical Differences in Carrier Isotypes and Their Distribution 1
TLDR
This review summarizes present knowledge of the chemistry of histo‐blood group ABH and related antigens and indicates that at least six types of A determinants can be distinguished by qualitatively different classes of antibody. Expand
Genetics of ABO, H, Lewis, X and Related Antigens
TLDR
The phylogeny of ABH determinants shows that they appeared as tissular antigens much earlier than as red cellAntigens, and an effort is made to correlate their tissular distribution in the adult with the embryological origin of each tissue. Expand
An α-d-galactosyltransferase associated with the blood-group B character
The blood-group substances in human secretions with immunological specificities related to the A, B, H and Lea antigens on the erythrocyte surface are glycoproteins having a major carbohydrateExpand
Deletion of histo-blood group A and B antigens and expression of incompatible A antigen in ovarian cancer.
TLDR
Findings clearly identified the specific expression of incompatible A antigen with the structure monofucosyl type 1 chain A (ALed) in tumors from histo-blood group B and O individuals. Expand
Repetitive A epitope (type 3 chain A) defined by blood group A1-specific monoclonal antibody TH-1: chemical basis of qualitative A1 and A2 distinction.
TLDR
The IgG2a monoclonal antibody TH-1, which reacts specifically with blood group A1 but with neither A2 nor O erythrocytes, has been established and is hereby called type 3 chain A. Expand
Murine monoclonal antibodies directed to the human histo-blood group A transferase (UDP-GalNAc:Fuc alpha 1----2Gal alpha 1----3-N-acetylgalactosaminyltransferase) and the presence therein of N-linked histo-blood group A determinant.
TLDR
Mouse MAbs to the human histo-blood group A glycosyltransferase were established by immunization with the purified native A transferase protein and antibodies stained the Golgi area of cells in epithelia from A and B, but not O, individuals, indicating a cross-reactivity with B transferase. Expand
Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.
Two new methods were used to establish a rapid and highly sensitive prenatal diagnostic test for sickle cell anemia. The first involves the primer-mediated enzymatic amplification of specificExpand
Qualitative differences in the N-acetyl-D-galactosaminyltransferases produced by human A1 and A2 genes.
TLDR
When the A(1) and A(2) enzymes were compared, with lacto-N-fucopentaose I and 2'-fucosyllactose as acceptors, the enzymes differed in their cation requirements, pH optima, and K(m) values. Expand
Stable expression of blood group H determinants and GDP-L-fucose: beta-D-galactoside 2-alpha-L-fucosyltransferase in mouse cells after transfection with human DNA.
TLDR
Results show that transfected human DNA sequences determine expression of the (alpha-1,2)fucosyltransferases in the mouse transfectants, that these sequences represent a single locus, and that they are within or linked to specific human restriction fragments identifiable in each secondary transfectant. Expand
...
1
2
3
4
...