Molecular genetic and epigenetic analysis of NCX2/SLC8A2 at 19q13.3 in human gliomas.

@article{Qu2010MolecularGA,
  title={Molecular genetic and epigenetic analysis of NCX2/SLC8A2 at 19q13.3 in human gliomas.},
  author={Mingqi Qu and Hua-bo Jiao and Juan Zhao and Z Ren and Anja Smits and Juha Kere and Monica Nist{\'e}r},
  journal={Neuropathology and applied neurobiology},
  year={2010},
  volume={36 3},
  pages={198-210}
}
AIM Loss of heterozygosity at 19q13.3 is a common genetic change in human gliomas, indicating yet unknown glial-specific tumour suppressor genes in this chromosome region. NCX2/SLC8A2 located on chromosome 19q13.32 encodes a Na(+)/Ca(2+) exchanger, which contributes to intracellular Ca(2+) homeostasis. Its expression is restricted to brain, and it is present neither in other normal tissues nor in gliomas at any significant level. The aim of this study was to investigate if NCX2 might be a… CONTINUE READING