Molecular genetic analysis reveals chromosomal deletion, gene amplification, and autocrine growth factor production in the pathogenesis of human lung cancer.

@article{Minna1986MolecularGA,
  title={Molecular genetic analysis reveals chromosomal deletion, gene amplification, and autocrine growth factor production in the pathogenesis of human lung cancer.},
  author={John D. Minna and James F. Battey and Burke J. Brooks and Frank Cuttitta and Adi F. Gazdar and Bruce Evan Johnson and Daniel C. Ihde and Anne-Marie Lebacq-Verheyden and James Mulshine and Marion M. Nau},
  journal={Cold Spring Harbor symposia on quantitative biology},
  year={1986},
  volume={51 Pt 2},
  pages={843-53}
}
These studies of lung cancer suggest that a number of molecular mechanisms may be important in the pathogenesis of lung cancer, especially SCLC. An inherited predisposition to develop SCLC may correlate with a nonfunctional, recessive allele for a gene (McKusick #18228, McKusick 1986) that maps to chromosome region 3p(14-23). Individuals at risk would be heterozygous for this allele in their germ line, carrying one copy of a normal functional gene and one mutant, recessive allele. Exposure to… CONTINUE READING

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