Molecular genetic analysis of the von Hippel-Lindau disease tumor suppressor gene in familial and sporadic cerebellar hemangioblastomas.

@article{Tse1997MolecularGA,
  title={Molecular genetic analysis of the von Hippel-Lindau disease tumor suppressor gene in familial and sporadic cerebellar hemangioblastomas.},
  author={Jorden Tse and John Tai-hung Wong and Kwok Wai Lo and Wai Sang Poon and Dolly Poon Wai Sin Huang and Ho Keung Ng},
  journal={American journal of clinical pathology},
  year={1997},
  volume={107 4},
  pages={459-66}
}
Cerebellar hemangioblastoma is one of the most frequent manifestations of the autosomal dominantly inherited von Hippel-Lindau (VHL) disease but also may manifest as a sporadic tumor. The purpose of this study was to define the alterations of the VHL gene in hemangioblastomas. We analyzed nine specimens from eight cerebellar hemangioblastomas (three familial and five sporadic) and six blood samples from family members of two unrelated pedigrees for mutations of the VHL gene using single-strand… CONTINUE READING