Molecular genetic analysis of sexual rejection: roles of octopamine and its receptor OAMB in Drosophila courtship conditioning.

@article{Zhou2012MolecularGA,
  title={Molecular genetic analysis of sexual rejection: roles of octopamine and its receptor OAMB in Drosophila courtship conditioning.},
  author={Chuan Zhou and Hai Huang and Susy M Kim and Hsuanwen Lin and Xianglan Meng and Kyung-An Han and A. M. Chiang and Jing W. Wang and Renjie Jiao and Yi Rao},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2012},
  volume={32 41},
  pages={14281-7}
}
After Drosophila males are rejected by mated females, their subsequent courtship is inhibited even when encountering virgin females. Molecular mechanisms underlying courtship conditioning in the CNS are unclear. In this study, we find that tyramine β hydroxylase (TβH) mutant males unable to synthesize octopamine (OA) showed impaired courtship conditioning, which could be rescued by transgenic TβH expression in the CNS. Inactivation of octopaminergic neurons mimicked the TβH mutant phenotype… CONTINUE READING
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