Molecular genetic analysis of glucocorticoid signalling in development.

  title={Molecular genetic analysis of glucocorticoid signalling in development.},
  author={Wolfgang Schmid and Timothy J Cole and Julie A. Blendy and G. Sch{\"u}tz},
  journal={The Journal of steroid biochemistry and molecular biology},
  volume={53 1-6},
A null mutation of the glucocorticoid receptor was generated by homologous recombination. Mutant newborn mice showed impaired lung development, hypertrophy of the adrenal cortex and a strongly reduced size of the adrenal medulla. Phenylethanolamine N-methyltransferase (PNMT) was undetectable in the adrenals of the mutant mice. Serum levels of corticosterone were moderately and ACTH levels were strongly elevated in the mutants. A weaker but significant increase of corticosterone and ACTH was… CONTINUE READING
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