Molecular genetic analysis of Down syndrome

  title={Molecular genetic analysis of Down syndrome},
  author={D. Patterson},
  journal={Human Genetics},
  • D. Patterson
  • Published 2009
  • Biology, Medicine
  • Human Genetics
  • Down syndrome (DS) is caused by trisomy of all or part of human chromosome 21 (HSA21) and is the most common genetic cause of significant intellectual disability. In addition to intellectual disability, many other health problems, such as congenital heart disease, Alzheimer’s disease, leukemia, hypotonia, motor disorders, and various physical anomalies occur at an elevated frequency in people with DS. On the other hand, people with DS seem to be at a decreased risk of certain cancers and… CONTINUE READING
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