Molecular genetic analysis of Down syndrome

@article{Patterson2009MolecularGA,
  title={Molecular genetic analysis of Down syndrome},
  author={David Patterson},
  journal={Human Genetics},
  year={2009},
  volume={126},
  pages={195-214}
}
  • D. Patterson
  • Published 13 June 2009
  • Biology, Medicine
  • Human Genetics
Down syndrome (DS) is caused by trisomy of all or part of human chromosome 21 (HSA21) and is the most common genetic cause of significant intellectual disability. In addition to intellectual disability, many other health problems, such as congenital heart disease, Alzheimer’s disease, leukemia, hypotonia, motor disorders, and various physical anomalies occur at an elevated frequency in people with DS. On the other hand, people with DS seem to be at a decreased risk of certain cancers and… 
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Down syndrome (DS) also known as trisomy 21 is a genetic complex disorder and the most common and best known autosomal chromosome abnormality in humans. Even though the majority of cases of DS can be
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