Molecular genetic analysis and regulation of aflatoxin biosynthesis

@article{Bhatnagar2003MolecularGA,
  title={Molecular genetic analysis and regulation of aflatoxin biosynthesis},
  author={Deepak Bhatnagar and Kenneth C. Ehrlich and Thomas E. Cleveland},
  journal={Applied Microbiology and Biotechnology},
  year={2003},
  volume={61},
  pages={83-93}
}
Aflatoxins, produced by some Aspergillus species, are toxic and extremely carcinogenic furanocoumarins. Recent investigations of the molecular mechanism of AFB biosynthesis showed that the genes required for biosynthesis are in a 70 kb gene cluster. They encode a DNA-binding protein functioning in aflatoxin pathway gene regulation, and other enzymes such as cytochrome P450-type monooxygenases, dehydrogenases, methyltransferases, and polyketide and fatty acid synthases. Information gained from… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 77 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 126 references

Insect interaction with mycotoxin-producing fungi and their hosts

PF Dowd
DK (eds) Handbook of applied mycology, • 1992
View 4 Excerpts
Highly Influenced

2000a) Aflatoxins: biological significance and regulation of biosynthesis

JW Cary, JE Linz, D Bhatnagar
2000
View 5 Excerpts
Highly Influenced

Aflatoxins : biological significance and regulation of biosynthesis

JW Cary, JE Linz, D Bhatnagar
2000
View 5 Excerpts
Highly Influenced

The natural functions of secondary metabolites.

Advances in biochemical engineering/biotechnology • 2000
View 4 Excerpts
Highly Influenced

Cloning of the afl-2 gene involved in aflatoxin biosynthesis from Aspergillus flavus

GA Payne, GJ Nystorm, D Bhatnagar, TE Cleveland, CP Woloshuk
Appl Environ Microbiol • 1993
View 3 Excerpts
Highly Influenced

Aflatoxin: an ecologically elicited genetic activation signal. In: Smith JE, Henderson RS (eds) Mycotoxins and animal foods

EB Lillehoj
1991
View 4 Excerpts
Highly Influenced

Aflatoxin and sclerotial production by Aspergillus flavus: influence of pH

P Cotty
Phytopathology • 1988
View 6 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…