Molecular functions of syndecan-1 in disease.

  title={Molecular functions of syndecan-1 in disease.},
  author={Yvonne Hui-Fang Teng and Rafael S Aquino and Pyong Woo Park},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  volume={31 1},
Syndecan-1 is a cell surface heparan sulfate proteoglycan that binds to many mediators of disease pathogenesis. Through these molecular interactions, syndecan-1 can modulate leukocyte recruitment, cancer cell proliferation and invasion, angiogenesis, microbial attachment and entry, host defense mechanisms, and matrix remodeling. The significance of syndecan-1 interactions in disease is underscored by the striking pathological phenotypes seen in the syndecan-1 null mice when they are challenged… CONTINUE READING

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