Molecular forms of adrenomedullin in pericardial fluid and plasma in patients with ischaemic heart disease.

@article{Nishikimi2002MolecularFO,
  title={Molecular forms of adrenomedullin in pericardial fluid and plasma in patients with ischaemic heart disease.},
  author={Toshio Nishikimi and Ikuko Shibasaki and Hiroshi Iida and Hiroshi Asakawa and Yasushi Matsushita and Hideaki Mori and Yoshihiko Mochizuki and Yoshitaka Okamura and Shigeo Horinaka and Kenji Kangawa and Koichiro Shimada and Hiroaki Matsuoka},
  journal={Clinical science},
  year={2002},
  volume={102 6},
  pages={669-77}
}
Experimental studies have demonstrated that adrenomedullin (AM) has a positive inotropic action and exerts inhibitory effects against ventricular remodelling as an autocrine and paracrine factor. However, there is no clinical evidence for AM acting as a local regulator in the human heart. We measured the levels of various molecular forms of AM, i.e. an active form of mature AM (AM-m), an intermediate inactive form of glycine-extended AM (AM-Gly) and total AM (AM-T=AM-m+AM-Gly), in plasma and… CONTINUE READING
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