Molecular forms of acetylcholinesterases in Alzheimer's disease.

@article{Younkin1986MolecularFO,
  title={Molecular forms of acetylcholinesterases in Alzheimer's disease.},
  author={Samuel G. Younkin and B Goodridge and Joseph Katz and G Lockett and Daniel A Nafziger and M F Usiak and Linda H. Younkin},
  journal={Federation proceedings},
  year={1986},
  volume={45 13},
  pages={2982-8}
}
In this study, we examined 26 cases of Alzheimer's disease (AD) and 14 age-matched controls. In Brodmann area 21 cerebral cortex of the AD cases, there was no change in soluble G1 and G4 acetylcholinesterase (AChE) (EC 3.1.1.7), a significant 40% decrease in membrane-associated G4 AChE, significant 342 and 406% increases in A12 and A8 AChE, and a significant 71% decrease in choline acetyltransferase (ChAT) (EC 2.3.1.6). Our working hypothesis to account for these changes postulates that soluble… CONTINUE READING

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