Molecular footprint of drug-selective pressure in a human immunodeficiency virus transmission chain.

@article{Lemey2005MolecularFO,
  title={Molecular footprint of drug-selective pressure in a human immunodeficiency virus transmission chain.},
  author={Philippe Lemey and Inge Derdelinckx and Andrew Rambaut and Kristel Van Laethem and St{\'e}phanie Dumont and Steve Vermeulen and Eric van Wijngaerden and Anne-Mieke Vandamme},
  journal={Journal of virology},
  year={2005},
  volume={79 18},
  pages={11981-9}
}
Known human immunodeficiency virus (HIV) transmission histories are invaluable models for investigating the evolutionary and transmission dynamics of the virus and to assess the accuracy of phylogenetic reconstructions. Here we have characterized an HIV-1 transmission chain consisting of nine infected patients, almost all of whom were treated with antiviral drugs at later stages of infection. Partial pol and env gp41 regions of the HIV genome were directly sequenced from plasma viral RNA for at… CONTINUE READING