Molecular fingerprinting reveals non-overlapping T cell oligoclonality between an inflamed site and peripheral blood.

@article{Wedderburn1999MolecularFR,
  title={Molecular fingerprinting reveals non-overlapping T cell oligoclonality between an inflamed site and peripheral blood.},
  author={L R Wedderburn and Mala K Maini and Amit Patel and Peter Beverley and Patricia Woo},
  journal={International immunology},
  year={1999},
  volume={11 4},
  pages={535-43}
}
We have demonstrated a stable expansion of CD8+ T cells in the peripheral blood of a child with chronic arthritis. The expanded TCRBV family (TCRBV14) was enriched for CD57hiCD28- T cells. Sequencing of the TCRBV14 amplification products showed a TCR sequence which contributed 32% of the total TCR in the CD8+TCRBV14 population. Using the modified heteroduplex technique, the CD8+TCRBV14 cells showed a clonal pattern and these bands were restricted to the CD28- population. This method also… CONTINUE READING
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