Molecular features of the sortase enzyme family.

  title={Molecular features of the sortase enzyme family.},
  author={William J Bradshaw and Abigail Davies and Christopher J. Chambers and April K. Roberts and Clifford C. Shone and Keshab R. Acharya},
  journal={The FEBS journal},
  volume={282 11},
Bacteria possess complex and varying cell walls with many surface exposed proteins. Sortases are responsible for the covalent attachment of specific proteins to the peptidoglycan of the cell wall of Gram-positive bacteria. Sortase A of Staphylococcus aureus, which is seen as the archetypal sortase, has been shown to be essential for pathogenesis and has therefore received much attention as a potential target for novel therapeutics. Being widely present in Gram-positive bacteria, it is likely… CONTINUE READING
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