Molecular features of neonicotinoid pharmacophore variants interacting with the insect nicotinic receptor.

@article{Ohno2009MolecularFO,
  title={Molecular features of neonicotinoid pharmacophore variants interacting with the insect nicotinic receptor.},
  author={Ikuya Ohno and Motohiro Tomizawa and Kathleen A. Durkin and Yuji Naruse and John E. Casida and Shinzo Kagabu},
  journal={Chemical research in toxicology},
  year={2009},
  volume={22 3},
  pages={476-82}
}
Molecular interactions of neonicotinoid insecticides with the nicotinic acetylcholine receptor have been mapped by chemical and structural neurobiology approaches, thereby encouraging the biorational design of novel nicotinic ligands. This investigation designs, prepares, and evaluates the target site potency of neonicotinoid analogues with various types of electronegative pharmacophores and subsequently predicts their molecular recognition in the ligand-binding pocket. The N-nitroimino (NNO2… CONTINUE READING