Molecular evolution of the toll-like receptor multigene family in birds.

  title={Molecular evolution of the toll-like receptor multigene family in birds.},
  author={Miguel Alcaide and Scott V Edwards},
  journal={Molecular biology and evolution},
  volume={28 5},
Toll-like receptors (TLR) are membrane-bound sensors of the innate immune system that recognize invariant and distinctive molecular features of invading microbes and are also essential for initiating adaptive immunity in vertebrates. The genetic variation at TLR genes has been directly related to differential pathogen outcomes in humans and livestock. Nonetheless, new insights about the impact of TLRs polymorphism on the evolutionary ecology of infectious diseases can be gained through the… CONTINUE READING
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