Molecular evolution of the metaplasia-dysplasia-adenocarcinoma sequence in the esophagus.

Abstract

The incidence of adenocarcinoma of the esophagus has been increasing in developing countries over the last three decades and probably reflects a genuine increase in the incidence of its recognized precursor lesion, Barrett's metaplasia. Despite advances in multimodality therapy, the prognosis for invasive esophageal adenocarcinoma is poor. An improved… (More)

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