Molecular evolution of the human adult alpha-globin-like gene region: insertion and deletion of Alu family repeats and non-Alu DNA sequences.

@article{Hess1983MolecularEO,
  title={Molecular evolution of the human adult alpha-globin-like gene region: insertion and deletion of Alu family repeats and non-Alu DNA sequences.},
  author={John F. Hess and Miles Fox and C Schmid and Clifton Kwang-Fu Shen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1983},
  volume={80 19},
  pages={
          5970-4
        }
}
Previous heteroduplex studies have revealed extensive sequence homology between the two human adult alpha-globin-like genes (alpha 2 and alpha 1) and their flanking regions. These homologous regions, which are interrupted by two blocks of nonhomology, each span approximately 4 kilobases [Lauer, J., Shen, C.-K. J. & Maniatis, T. (1980) Cell 20, 119-130]. We have determined 3 kilobases of DNA sequences within and flanking the nonhomologous blocks of these two tandem duplication units. A total of… CONTINUE READING

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