Molecular evolution of the VP1, VP2, and VP3 genes in human rhinovirus species C

  title={Molecular evolution of the VP1, VP2, and VP3 genes in human rhinovirus species C},
  author={Makoto Kuroda and Shoichi Niwa and Tsuyoshi Sekizuka and Hiroyuki Tsukagoshi and Masaru Yokoyama and Akihide Ryo and Hironori Sato and Naoko Kiyota and Masahiro Noda and Kunihisa Kozawa and Komei Shirabe and Takashi Kusaka and Naoki Shimojo and Shunji Hasegawa and Kazuko Sugai and Masatsugu Obuchi and Masato Tashiro and Kazunori Oishi and Haruyuki Ishii and Hirokazu Kimura},
  booktitle={Scientific reports},
Human rhinovirus species C (HRV-C) was recently discovered, and this virus has been associated with various acute respiratory illnesses (ARI). However, the molecular evolution of the major antigens of this virus, including VP1, VP2, and VP3, is unknown. Thus, we performed complete VP1, VP2, and VP3 gene analyses of 139 clinical HRV-C strains using RT-PCR with newly designed primer sets and next-generation sequencing. We assessed the time-scale evolution and evolutionary rate of these genes… CONTINUE READING
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