Molecular evolution of cytochrome c oxidase: rate variation among subunit VIa isoforms.

@article{Schmidt1997MolecularEO,
  title={Molecular evolution of cytochrome c oxidase: rate variation among subunit VIa isoforms.},
  author={Timothy R. Schmidt and Saied A. Jaradat and Morris Goodman and M. I. Lomax and Lawrence I. Grossman},
  journal={Molecular biology and evolution},
  year={1997},
  volume={14 6},
  pages={595-601}
}
Cytochrome c oxidase (COX) consists of 13 subunits, 3 encoded in the mitochondrial genome and 10 in the nucleus. Little is known of the role of the nuclear-encoded subunits, some of which exhibit tissue-specific isoforms. Subunit VIa is unique in having tissue-specific isoforms in all mammalian species examined. We examined relative evolutionary rates for the COX6A heart (H) and liver (L) isoform genes along the length of the molecule, specifically in relation to the tissue-specific function(s… CONTINUE READING
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