Molecular evolution of beta-lactam-resistant Haemophilus influenzae: 9-year surveillance of penicillin-binding protein 3 mutations in isolates from Japan.

@article{Sanbongi2006MolecularEO,
  title={Molecular evolution of beta-lactam-resistant Haemophilus influenzae: 9-year surveillance of penicillin-binding protein 3 mutations in isolates from Japan.},
  author={Yumiko Sanbongi and Takahisa Suzuki and Yumi Osaki and Nami Senju and Takashi Ida and Kimiko Ubukata},
  journal={Antimicrobial agents and chemotherapy},
  year={2006},
  volume={50 7},
  pages={2487-92}
}
A total of 621 clinical isolates of Haemophilus influenzae collected in Japan between 1995 and 2003 were studied for their susceptibilities to several antimicrobial agents, beta-lactamase production, and amino acid substitutions in penicillin-binding protein 3 (PBP 3). Over the four study periods (first period, 1995 to 1996; second period, 1997 to 1998; third period, 2000 to 2001; fourth period, 2002 to 2003), the susceptibilities to beta-lactam agents decreased and the incidence of isolates… CONTINUE READING

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