Molecular evolution of a malaria resistance gene (DARC) in primates

  title={Molecular evolution of a malaria resistance gene (DARC) in primates},
  author={Thiago Y. K. Oliveira and Eugene E. Harris and Diogo Meyer and Chong K. Jue and Wilson Ara{\'u}jo Silva},
Genes involved in host–pathogen interactions are often strongly affected by positive natural selection. The Duffy antigen, coded by the Duffy antigen receptor for chemokines (DARC) gene, serves as a receptor for Plasmodium vivax in humans and for Plasmodium knowlesi in some nonhuman primates. In the majority of sub-Saharan Africans, a nucleic acid variant in GATA-1 of the gene promoter is responsible for the nonexpression of the Duffy antigen on red blood cells and consequently resistance to… CONTINUE READING