Molecular evolution of Keap1. Two Keap1 molecules with distinctive intervening region structures are conserved among fish.

@article{Li2008MolecularEO,
  title={Molecular evolution of Keap1. Two Keap1 molecules with distinctive intervening region structures are conserved among fish.},
  author={Li Li and Makoto Kobayashi and Hiroshi Kaneko and Yaeko Nakajima-Takagi and Yuko Nakayama and Masayuki Yamamoto},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 6},
  pages={3248-55}
}
Keap1 is a BTB-Kelch-type substrate adaptor protein of the Cul3-dependent ubiquitin ligase complex. Keap1 facilitates the degradation of Nrf2, a transcription factor regulating the inducible expression of many cytoprotective genes. Through comparative genome analyses, we found that amino acid residues composing the pocket of Keap1 that interacts with Nrf2 are highly conserved among Keap1 orthologs and related proteins in all vertebrates and in certain invertebrates, including flies and… CONTINUE READING
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