Molecular evolution and the global reemergence of enterovirus D68 by genome-wide analysis

  title={Molecular evolution and the global reemergence of enterovirus D68 by genome-wide analysis},
  author={Yu-Nong Gong and Shu-li Yang and Shin-Ru Shih and Yhu-Chering Huang and Pi-yueh Chang and Chung-Guei Huang and Kuo-Chin Kao and Han-Chung Hu and Yi-Chun Liu and Kuo Chien Tsao},
Abstract Human enterovirus D68 (EV-D68) was first reported in the United States in 1962; thereafter, a few cases were reported from 1970 to 2005, but 2 outbreaks occurred in the Philippines (2008) and the United States (2014). However, little is known regarding the molecular evolution of this globally reemerging virus due to a lack of whole-genome sequences and analyses. Here, all publically available sequences including 147 full and 1248 partial genomes from GenBank were collected and compared… 
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Intra- and interpatient evolution of enterovirus D68 analyzed by whole-genome deep sequencing
A comprehensive description of the intra- and interpatient evolution of EV-D68 is provided, including the first report of intrapatient diversity and dual infections, which are included in an interactive phylodynamic analysis on
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  • 2019
Molecular diversity and biennial circulation of enterovirus D68: a systematic screening study in Lyon, France, 2010 to 2016
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Phylogenetic analyses showed ongoing diversification of EV-D68 worldwide, coinciding with more infections in recent years and increases of reported AFM paediatric cases and rises of the effective population size in Lyon coincided with infection upsurges.
Distinct genetic clades of enterovirus D68 detected in 2010, 2013, and 2015 in Osaka City, Japan
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The evolutionary history of this outbreak of enterovirus D68 was characterized in detail, an intersubclade recombination event was identified, and whether there was any correlation between the demographic and clinical characteristics of the patients and the viral variant that infected them was investigated.
Analysis of Enterovirus 68 Strains from the 2014 North American Outbreak Reveals a New Clade, Indicating Viral Evolution
Results indicate that members of Clade B containing highly specific alterations in VP1 protein residues were the foremost contributors to the 2014 outbreak in the US and may explain the evolution of EVD68 as well as the global emergence and ongoing adaptation of this virus.
Molecular and epidemiological study of enterovirus D68 in Taiwan.
Worldwide emergence of multiple clades of enterovirus 68.
Phylogenetic analysis of all EV-D68 sequences indicates that multiple clades of the virus have emerged and spread rapidly worldwide, and all clades appear to be currently circulating and contributing to respiratory disease.
Reemergence of Enterovirus 71 Epidemic in Northern Taiwan, 2012
Genotype B5 and C4a viruses antigenically differ from genotype A viruses which have disappeared globally for 30 years but have been detected in China since 2008.
Molecular Epidemiology and Evolution of Human Enterovirus Serotype 68 in Thailand, 2006–2011
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Global reemergence of enterovirus D68 as an important pathogen for acute respiratory infections
Enterovirus D68 (EV‐D68) is detected in children with severe acute respiratory infections in the Philippines in 2008–2009 and is now recognized as a reemerging pathogen, although the epidemiological profile and clinical significance of EV‐D 68 is yet to be defined, and the virological characteristics are not fully understood.