Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene (FMO3)

  title={Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene (FMO3)},
  author={C. Allerston and Makiko Shimizu and M. Fujieda and E. Shephard and H. Yamazaki and I. R. Phillips},
  journal={Pharmacogenetics and Genomics},
  • C. Allerston, Makiko Shimizu, +3 authors I. R. Phillips
  • Published 2007
  • Biology, Medicine
  • Pharmacogenetics and Genomics
  • Objectives Flavin-containing monooxygenase 3 (FMO3) is involved in the metabolism of foreign chemicals, including therapeutic drugs, and thus mediates interactions between humans and their chemical environment. Loss-of-function mutations in the gene cause the inherited disorder trimethylaminuria, or fish-odour syndrome. The objective was to gain insights into the evolutionary history of FMO3. Methods Genetic diversity within FMO3 was characterized by sequencing 6.3 kb of genomic DNA… CONTINUE READING
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